Statistik-Beratung ROC analysis, ROC curves


Willkommen ! English Version Biometrie & Statistik Schwerpunkt Diagnostik Schwerpunkt Labor Statistische Beratung Schwerpunkt Software Referenzen/Projekte Projekte Referenzen Links ACOMED Kontakt / Anfahrt Vorstellung Stellenangebote / Praktika Ablauf / Konditionen Impressum


E. Meisel: Der Kuss der Amphibie (
disease cluster

Sie befinden sich: Projekte/Referenzen - Literatur

Literaturverzeichnis Dr. Thomas Keller, ACOMED statistik, Leipzig


Bach T, Bastian P, Blana A, Kaminsky A, Keller S, Knoll T, Lang C, Promnitz S, Ubrig B, Keller T, Qvick B, Burger M; OPTIC III Study Group (2016). Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III. World J Urol.; DOI: 10.1007/s00345-016-1925-0

Reimer M, Hüllemann P, Hukauf M, Keller T, Binder A, Gierthmühlen J, Baron R (2016). Prediction of response to tapentadol in chronic low back pain. Eur J Pain., DOI: 10.1002/ejp.926

Hüllemann P, Keller T, Kabelitz M, Freynhagen R, Tölle T, Baron R (2016). Pain Drawings Improve Subgrouping of Low Back Pain Patients. Pain Practice, DOI: 10.1111/papr.12470

Förster M, Helfert S, Dierschke R, Großkopf M, Hüllemann P, Keller T, Baron R, Binder A (2016). Evaluation of the antihyperalgesic effect of tapentadol in two human evoked pain models - the TapCapMentho pilot trial. Expert Opin Pharmacother. DOI: 10.1080/14656566.2016.1201071

Lorenz K, Keller T, Noack B, Freitag A, Netuschil L, Hoffmann T (2016). Evaluation of a novel point‐of‐care test for active matrix metalloproteinase‐8: agreement between qualitative and quantitative measurements and relation to periodontal inflammation. J Periodontal Res. DOI: 10.1111/jre.1239

Kasimir-Bauer S, Bittner A-K, König L, Reiter K, Keller T, Kimmig R, Hoffmann O (2016). Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy. Breast Cancer Res 18:20

Keller T, Freynhagen R, Tölle TR, Liwowsky I, Möller P, Hüllemann P, Gockel U, Stemmler E, Baron R. (2015): A retrospective analysis of the long-term test-retest stability of pain descriptors of the painDETECT-Questionnaire. Curr Med Res Opin. 4:1-22

Hagen A, Albig M, Keller T, Stumm M, Entezami M (2015). Suspicious Prenasal Skin Thickness-to-Nasal Bone Length Ratio: Prevalence and Correlation with Other Markers in Second and Third Trimester Fetuses with Down Syndrome. Ultraschall in Med. DOI

Zscharnack M, Krause C, Aust G, Thümmler C, Peinemann F, Keller T, Smink JJ, Holland H, Somerson JS, Knauer J, Schulz RM, Lehmann J (2015). Preclinical good laboratory practice-compliant safety study to evaluate biodistribution and tumorigenicity of a cartilage advanced therapy medicinal product (ATMP). J Transl Med. 2015 May 20;13:160. doi: 10.1186/s12967-015-0517-x

Bergeron, C, Ikenberg, H, Sideri, M, Denton, K, Bogers, J, Schmidt, D, Alameda, F, Keller, T, Rehm, S, Ridder, R and for the PALMS Study Group (2015), Prospective evaluation of p16/Ki-67 dual-stained cytology for managing women with abnormal Papanicolaou cytology: PALMS study results. Cancer Cytopathology. doi: 10.1002/cncy.21542

Köckerling F, Bittner R, Jacob DA, Seidelmann L, Keller T, Adolf D, Kraft B, Kuthe A (2015). TEP versus TAPP: comparison of the perioperative outcome in 17,587 patients with a primary unilateral inguinal hernia. Surg Endosc. 2015 Mar 25. [Epub ahead of print]

Köckerling F, Bittner R, Jacob D, Schug-Pass C, Laurenz C, Adolf D, Keller T, Stechemesser B (2015). Do we need antibiotic prophylaxis in endoscopic inguinal hernia repair? Results of the Herniamed Registry. Surg Endosc. 2015 Mar 19. [Epub ahead of print]

Becker R, Keller T, Wegner RD, Neitzel H, Stumm M, Knoll U, Stärk M, Fangerau H, Bittles A (2014). Consanguinity and pregnancy outcomes in a multi-ethnic, metropolitan European population. Prenat Diagn. 13, 1-9

Kuhlmann JD, Wimberger P, Bankfalvi A, Keller T, Schöler S, Aktas B, Buderath P, Hauch S, Otterbach F, Kimmig R, Kasimir-Bauer S (2014). ERCC1-Positive Circulating Tumor Cells in the Blood of Ovarian Cancer Patients as a Predictive Biomarker for Platinum Resistance. Clin Chem. 2014 Jul 11. pii: clinchem.2014.224808. [Epub ahead of print]

Keller T, Brinkmann T (2014). Proposed Guidance for Carryover Studies, Based on Elementary Equivalence Testing. Clin. Lab 7,1153-61

Goossens K, De Grande LA, Keller T, Weber S, Thienpont LM (2014). Verification of reference intervals by the C28 protocol - The alpha error/power trade-off. Clin Chim Acta 436, 18-19

Favrat B, Balck K, Breymann C, Hedenus M, Keller T, Mezzacasa A, Gasche C (2014). Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women - PREFER a randomized, placebo-controlled study, PLoS One 9, e94217 (doi: 10.1371/journal.pone.0094217)

Mick G, Baron R, Correa-Illanes G, Hans G, Mayoral V, Frías X, Sintes D, Keller T (2014). Is an easy and reliable diagnosis of localized neuropathic pain (LNP) possible in general practice? Development of a screening tool based on IASP criteria. Curr Med Res Opin, Epub ahead of print

Oelkrug C, Hilger N, Schönfelder U, Boltze J, Sack U, Fricke C, Hildebrandt G, Keller T, Emmrich F, Fricke S (2014). Modelling hematological parameters after total body irradiation. International Journal of Radiation Biology; DOI:10.3109/09553002.2014.899443

Ikenberg H, Bergeron C, Schmidt D, Griesser H, Alameda F, Angeloni C, Bogers J, Dachez R, Denton K, Hariri J, Keller T, von Knebel Doeberitz M, Neumann MH, Puig-Tintore LM, Sideri M, Rehm S, Ridder R for the PALMS study group (2013). Screening for Cervical Cancer Precursors with p16/Ki-67 Dual-stained Cytology: Results of the PALMS Study. J Natl Cancer Inst 105, 1550-7

Krell PF, Reuther S, Fischer U, Keller T, Weber S, Gombert M, Schuster FR, Asang C, Stepensky P, Strahm B, Meisel R, Stoye J, Borkhardt A (2013). Next-generation-sequencing-spectratyping reveals public T-cell receptor repertoires in pediatric very severe aplastic anemia and identifies a beta chain CDR3 sequence associated with hepatitis-induced pathogenesis. Haematologica 98, 1388-96

Keller T, Baron R, Freynhagen R, Gockel U, Kohlmann T, Knoll C, Stemmler E and Tölle TR (2013). New insights into disease-specific patterns of neuropathic pain symptoms using the painDETECT-questionnaire with a simple standardization procedure. NeuPSIG 2013, Band of Abstracts. Abstract. Poster.

Baron R, Freynhagen R, Gockel U, Kohlmann T, Keller T, Stemmler E and Tölle TR (2013). Test and re-test of the painDETECT-questionnaire. NeuPSIG 2013, Band of Abstracts. Abstract. Poster.

Zegers I, Beetham R, Keller T, Sheldon J, Bullock D, MacKenzie F, Trapmann S, Emons H and Schimmel H (2013). The Importance of Commutability of Reference Materials Used as Calibrators: The Example of Ceruloplasmin. Clin Chem. 2013 May 6. [Epub ahead of print]

Becker R, Keller T, Kiesewetter H, Fangerau H, Bittner U (2013). Individual risk assessment of adverse pregnancy outcome by multivariate regression analysis may serve as basis for drug intervention studies: retrospective analysis of 426 high-risk patients including ethical aspects. Arch Gynecol Obstet 281, 41-8

Hanke S, Hirschfelder U, Keller T, Hofmann E (2012). 3D CT based rating of unilateral impacted canines. J Craniomaxillofac Surg. 49, e268-76

Titiz I, Laubinger M, Keller T, Hertrich K and Hirschfelder U (2012): Repeatability and reproducibility of landmarks — a three-dimensional computed tomography study. Eur J Orthod. 34, 276-86

Neumann A, Keller T, Jocham D, Doehn C: Human placental alkaline phosphatase (hPLAP) is the most frequently elevated serum marker in testicular cancer]. Aktuelle Urol. 2011 Sep;42(5):311-5

Hoffmann T, Bruhn G, Lorenz K, Keller T, Netuschil L (2011). Agreement between qualitative aMMP-8 Chair side and quantitative ELISA Test. J Dent Res 90 (Spec Iss A), Abstr.# 323

Keller T, Faye S, Katzorke T (2011): Statistical Test for Equivalence in Analysis of Method Comparison Experiments. Application in comparison of AMH assays. CCLM 49, S 806, Download Poster

Auclair G, Keller T, Sinha P, Sheldon J, Rota F, Schimmel H, Zegers I (2011): Commutability study on ERM-DA472/IFCC, C-reactive protein in human serum. CCLM 49, S804

Fillée1 C, Keller T, Ketelslegers JM (2011): Vitamin-D related parathyroid hormone reference ranges and their impact on the diagnosis of mild primary hyperparathyroidism. CCLM 49, S423

Katzorke T, Faye SA, Keller T (2011): AMH GEN II: A Comparison of results versus DSL AMH ELISA and reference interval data. CCLM 49, S421

Hofmann E, Medelnik J, Keller T, Steinhäuser S, Hirschfelder U (2011): Measuring mesiodistal width of impacted maxillary canines: CT-assisted determination. J Orofac Orthop. 72, 33-44

Schuster FR, Hubner B, Führer M, Eckermann O, Gombert M, Dornmair K, Binder V, Reuther S, Krell P, Keller T and Borkhardt A (2011): Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal (2011) 1, e8; doi:10.1038/bcj.2011.6

Zegers I, Keller T, Schreiber W, Sheldon J, Albertini R, Blirup-Jensen S, Johnson M, Trapmann S, Emons H, Merlini G, Schimmel H (2010): Characterisation of ERM-DA470k/IFCC for 12 serum proteins. Clin Chem, 56:1880-1888

Zemlin AE, Essack Y, Rensburg M, Keller T, Brinkmann T (2010): Stability of Red Blood Cell Folate in Whole Blood and Haemolysate. Clin. Lab 56: 391-396

Keller T, Brinkmann T (2010): Statistical Test for Equivalence and Non-Inferiority in Analysis of Method Validation and Comparison Experiments: Application in Assessment of Carry-over. Clin Chem; 56 Suppl.: A222

Jung R, Jacobs U, Krumbholz M, Langer T, Keller T, De Lorenzo P, Valsecchi MG, van der Velden VH, Moericke M, Stanulla M, Harbott J, Panzer-Grumayer , van Dongen JJM, Pieters R, Schrappe M, Rascher W, Metzler M (2010): Bimodal distribution of genomic MLL breakpoints in infant acute lymphoblastic leukemia, Leukemia 24:903-907

Denton KJ, Bergeron C, Klement P, Trunk MJ, Keller T, Ridder R (2010): The sensitivity and specificity of p16INK4a Cytology versus HPV Testing for Detecting High-Grade Cervical Disease in the Triage of ASC-US and LSIL Pap Cytology Results. Am J Clin Pathol 134:12-21

Bergeron C, Ordi J, Schmidt D, Trunk MJ, Keller T, Ridder R (2010): Conjunctive p16INK4a Testing Significantly Increases Accuracy in Diagnosing High-Grade Cervical Intraepithelial Neoplasia. Am J Clin Pathol 133:395-406

Weber S, Keller T (2009): Statistical Analysis of Commutability Experiments: Application of equivalence test as an advantageous approach. CCLM 47, A22. Download Poster

Keller T, Weber S (2009): Statistical Test for Equivalence in Analysis of Commutability Experiments. CCLM 47, 376-377. Download Poster

Keller T, Brinkmann T (2009): Statistical Test for Equivalence and Noninferiority in Analysis of Method Validation and Comparison Experiments. Application in Assessment of Carry-Over. CCLM 47, 356-357. Download Poster

von Goessel H, Jacobs U, Semper S, Krumbholz M, Langer T, Keller T, Schrauder A, van der Velden VHJ, van Dongen JJM, Harbott J, Panzer-Grümayer ER, Schrappe M, Rascher W, Metzler M (2008): Cluster analysis of genomic ETV6-RUNX1 (TEL-AML1) fusion sites in childhood acute lymphoblastic leukemia. Leuk Res 33(8): 1082-8

Busch K, Keller T, Fuchs U, Yeh R-F, Harbott J, Klose I, Wiemels J, Novosel A, Reiter A and Borkhardt A (2007): Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma. Leukemia 21(8): 1739-51

Rombaux P, Bertrand B, Keller T, Mouraux A (2007): Clinical Significance of Olfactory Event-Related Potentials Related to Orthonasal and Retronasal Olfactory Testing. Laryngoscope, 117:1096–1101.

Schmerbach KI, Boeltzig CKM, Reif U, Wieser JC, Keller T, Grevel V (2007): In Vitro Comparison of Tibial Plateau Leveling Osteotomy with and Without Use of a Tibial Plateau Leveling Jig. Vet. Surg. 36: 156-163.

Keller T : Statistische Aspekte bei der Multiparameteranalyse. In: Sack U, Tárnok A, Rothe G (Hrsg.): Zelluläre Diagnostik. Grundlagen, Methoden und klinische Anwendungen der Durchflusszytometrie. Karger Basel, Freiburg (2007), 208-236

Sack U, Biereder B, Elouahidi T, Bauer K, Keller T, Trobs RB (2006): Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children. BMC Surg. 28, 6-15.

Jung K, Lein M, Butz H, Stephan C, Loening SA, Keller T (2006): New Insights into the Diagnostic Accuracy of Complexed and Total Prostate Specific Antigen Using Discordance Analysis Characteristics. Urology 175, 1275-1280

Müller V, Witzel I, Pantel K, Krenkel S, Lück HJ, Neumann R, Keller T, Dittmer J, Jänicke F, Thomssen C (2006): Prognostic and Predictive Impact of Soluble Epidermal Growth Factor Receptor (sEGFR) Protein in the Serum of Patients Treated with Chemotherapy for Metastatic Breast Cancer. Anticancer Res. 26, 1479-1488

Keller T, Butz H, Lein M, Kwiatowski M, Semjonow A, Luboldt H-J, Hammerer P, Stephan C, Jung K (2005): Discordance Analysis Characteristics (DAC) as a New Method to Compare the Diagnostic Accuracy of Tests: the Example of Complexed Versus Total Prostate-Specific Antigen. Clin Chem 51, 532-539

Heiss C, Hoesel LM, Wehr U, Keller T, Horas U, Meyer C, Rambeck W, Schnettler R (2004): Vitamin K in combination with other biochemical markers to diagnose osteoporosis. Biomarkers 9, 479-488

Heiss C, Keller T, Wehr U, Mohr A, Lommel D, Meyer Ch, Rambeck WA, Schnettler R (2004): Biochemical Markers and their Significance in Postmenopausal Osteoporosis - A new Method in the Diagnosis of Osteoporosis? Biomed Technik 49: 262-268s

Wilda M, Busch K, Klose I, Keller T, Woessmann W, Kreuder J, Harbott J, Borkhardt A (2004): The level of MYC overexpression in pediatric Burkitt´s lymphoma is strongly dependent on the genomic breakpoint location within the MYC locus. Genes, Chromosomes & Cancer 41:178-82

Heiss C, Keller T, Wehr U, Pausch M, Horas U, Kilian O, Rambeck WA, Schnettler R (2003): Die Bewertung von biochemischen Knochenmarkerprofilen in der Diagnostik der Osteoporose (The Assessment of Biochemical Marker Profiles in Diagnosis of Osteoporosis). Akt Rheumatol 28: 164-171

Busch K, Keller T, Klose I, Harbott J, Reiter A and Borkhardt A (2003): Distribution of genomic breakpoints in children with Burkitt´s Lymphoma/ Leukemia (Poster). J Ped Haematol Oncol 25(4): S16-S17

Nuber A, Keller T, Bitterlich N, Gillissen A, Leonhardt P (2002): Diagnosis And Monitoring Of Therapy Of Lung Cancer With A Tumor Marker Profile: Comparing CYFRA 21-1, CEA And NSE With Fuzzy Logic-Based Tumor Marker Profiles. 98th International Conference of the American Thoracic Society, May 17-22, Atlanta, Band of Abstracts, p. A48

Keller T (2001): (eingeladener Vortrag) Enhancing clinical value of tumor markers with Fuzzy Logic. XXIX meeting of International Society for Oncodevelopmental Biology and Medicine (ISOBM), Barcelona, sept. 29th - oct. 3rd , 2001, Band of abstracts, p. SS20

Keller T (2000): (eingeladener Vortrag) Fuzzy logic approach for enhancing the diagnosis of cancer. XXVIII meeting of International Society for Oncodevelopmental Biology and Medicine (ISOBM) Munich, 2000, Tumor Biology 21 S1: 15

Halm U, Rohde N, Klapdor R, Reith HB, Thiede A, Etzrodt G, Mossner J, Keller T (2000): Improved sensitivity of fuzzy logic based tumor marker profiles for diagnosis of pancreatic carcinoma versus benign pancreatic disease. Anticancer Res. ; 20:4957-60

Keller T, Bigl H, Löser T, Leonhardt P (1998):Neue Möglichkeiten der Tumormarker-Diagnostik des Bronchialkarzinoms mittels fuzzy-basierter Auswertung von Tumormarkerprofilen (Poster). Pneumologie; 52: S33

Keller T, Bitterlich N, Hilfenhaus S, Bigl H, Löser T, Leonhardt P (1998): Tumour markers in the diagnosis of bronchial carcinoma: new options using fuzzy logic based tumour marker profiles. J Cancer Res Clin Oncol 124: 565-574

Keller T, Gehring L, Löser T (1998): Spurenelementverschiebungen bei Patienten mit chronischem Nierenversagen unter Dialyse. Nieren- und Hochdruckkrankheiten 27: 522-532

Lipp T, Lipp I, Keller F, Wolff F, Keller T (1994): Neue Aussagen zum Harnsteinleiden aus statistischer Sicht. Zeitschr. f. 17: 42

Pissarek P, Jähnichen F, Blasig IE, Haseloff R, Keller T, Tapp E, Krause E-G (1995): Cardioprotective potency of the radical scavenger S-2-(3 aminopropylamino) ethylphosphorothioic acid in the post-ischemic rat heart. Mol Cell Biochem. 145: 121-9

ROC curve, ROC curves, DAC method
Copyright: ACOMED   
{short description of image}
{short description of image} {short description of image} {short description of image}